1099 to 1477: from chapel to Renaissance basilica
The site begins with a chapel founded in 1099 and enlarged in 1227, then takes on its decisive form in the rebuilding commissioned by Sixtus IV between 1472 and 1477. That is why the church feels earlier than a Baroque showpiece but more coherent than many Roman interiors patched together over time. You are looking at a Renaissance framework that later artists kept enriching, not replacing.
Raphael, Agostino Chigi, and Bernini
The Chigi Chapel is where banker patronage turns into a masterclass in Roman ambition. Raphael designed the central-plan chapel for Agostino Chigi from 1513, drew the dome mosaics, and set up the funerary language; more than a century later, Bernini helped bring the space to completion. If you like seeing how one commission stretches across eras, this is the place to linger.
Caravaggio and Carracci in the Cerasi Chapel
Near the altar, the Cerasi Chapel pulls the church into the early 17th century with two Caravaggio canvases from around 1600-1601: the Conversion of St. Paul and the Crucifixion of St. Peter. Annibale Carracci's Assumption of the Virgin holds the center, which is why the chapel feels less like one isolated genius moment and more like a real artistic conversation.
The details people skip after Caravaggio
If you stop at the headline canvases, you miss the church's extra texture. There is Bramante's early-16th-century choir, Pinturicchio's frescoes in the Della Rovere Chapel, and a nave whose later decoration shows how much Bernini could alter mood without erasing what came before. Repeat visitors often enjoy this second layer more than the obvious highlights.